TOPIRAMATE

TOPIRAMATE

PRODUCT IDENTIFICATION

CAS NO.

97240-79-4

TOPIRAMATE

EINECS NO.

FORMULA C₁₂H₂₁NO₈S

MOL WT. 339.36

H.S. CODE

TOXICITY

SYNONYMS Topamax; Tracrium;

2,3:4,5-Bis-O-(1-methylethylidene)-beta-D-fructopyranose sulfamate; 2,3:4,5-Di-O-isopropylidene- beta-D-fructopyranose sulfamate;

SMILES

CLASSIFICATION

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE white crystalline powder

MELTING POINT 122 - 126 C

BOILING POINT 0.91 - 0.93

SPECIFIC GRAVITY

SOLUBILITY IN WATER Soluble

VAPOR DENSITY

AUTOIGNITION

NFPA RATINGS

Health: 1 Flammability: 1 Reactivity: 0

REFRACTIVE INDEX

FLASH POINT

STABILITY Stable under ordinary conditions

GENERAL DESCRIPTION AND APPLICATIONS

Topiramate is a sulfamated monose that interferes with calcium and sodium channels; used as an anticonvulsant in the treatment of some seizures including jerking of limbs, frothing at the mouth, and loss of consciousness due to a lesion in a specific cerebral cortex. Symptoms vary with different lesion locations. It is a white crystalline powder with a bitter taste; administered orally; soluble in acetone, chloroform, dimethylsulfoxide, ethanol and alkaline solutions; melting point 122 - 126 C. The chemical designation is 2,3:4,5-Bis-O-(1-methylethylidene)- beta-D-fructopyranose sulfamate.

APIs for Treatments of Alcohol Dependence
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Apraclonidine	66711-21-5
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Acamprosate calcium	77337-73-6
Acamprosate	77337-76-9
Topiramate	97240-79-4
Ondansetron hydrochloride dihydrate	99614-01-4
Ondansetron	99614-02-5
Ondansetron hydrochloride	103639-04-9

SALES SPECIFICATION

APPEARANCE

white crystalline powder

ASSAY

98.0% - 101.5%

LOSS ON DRYING

0.5% max

SULFATED ASH

0.1% max

MELTING POINT

122 - 126 C

HEAVY METALS

10ppm max

TRANSPORTATION

PACKING

HAZARD CLASS

UN NO.

OTHER INFORMATION

Hazard Symbols: XI, Risk Phrases:36/37/38, Safety Phrases:26-36
PRICE INFORMATION