SPARFLOXACIN

SPARFLOXACIN

PRODUCT IDENTIFICATION

CAS NO.

111542-93-9

SPARFLOXACIN

EINECS NO.

FORMULA C₁₉H₂₂F₂N₄O₃

MOL WT. 392.40

H.S. CODE

TOXICITY

DERIVATION

SYNONYMS AT-4140;

3-Quinolinecarboxylic acid, 5-amino-1-cyclopropyl-7-(3,5-dimethyl-1- piperazinyl)-6,8-difluoro- 1,4-dihydro-4-oxo-; 5-Amino-1-cyclopropyl-7-(cis-3,5-dimethyl-1-piperazinyl)-6,8-difluoro- 1,4-dihydro-4-oxo-3-quinolinecarboxylic acid;

CLASSIFICATION

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE off-white to yellow crystals

MELTING POINT

BOILING POINT

SPECIFIC GRAVITY

SOLUBILITY IN WATER Insoluble

VAPOR DENSITY

AUTOIGNITION

NFPA RATINGS

REFRACTIVE INDEX

FLASH POINT

STABILITY

Stable under ordinary conditions

GENERAL DESCRIPTION & APPLICATIONS

Fluoroquinolones belong to a group of synthetic antibiotics that are derived from basic structure of nalidixic acid and have substituents at N-1, C-5, C-7, position 8 and a fluorine atom at position 6. There are also polycyclic derivatives. Quinolone antibiotics have a ketone at position 4 and a carboxylic group at position 3. Fluoroquinolones inhibit the bacterial DNA gyrase or the topoisomerase IV enzyme, resulting the inhibition of DNA replication and transcription. Fluorine at position 6 enhances gyrase inhibition and cell penetration. Piperaziny substituents provide activity against Gram-negative bacteria and pyrrolidinyl moiety is active against Gram-positive cocci. They improve water solubility needed oral application. The function substituted at position 8 IS to control anaerobe activity.

Fluoroquinolone	Substituent
Substituted at N-1
Norfloxacin	Ethyl
Enoxacin	Ethyl
Lomefloxacin	Ethyl
Fleroxacin	Fluoro ethyl
Difloxacin	Fluorophenyl
Temafloxacin	Difluorophenyl
Trovafloxacin	Difluorophenyl
Amifloxacin	Methyl amino
Ciprofloxacin	Cyclopropyl
Grepafloxacin	Cyclopropyl
Alumofloxacin	Cyclopropyl
Gemifloxacin	Cyclopropyl
Moxifloxacin	Cyclopropyl
Ecenofloxacin	Cyclopropyl
Balofloxacin	Cyclopropyl
Substituted at C-5
Sparfloxacin	Amine
Grepafloxacin	Methyl
Substituted at C-7
Trovafloxacin	Bicyclic
Moxifloxacin	Bicyclic
Danafloxacin	Bicyclic
Garenoxacin	Bicyclic
Ciprofloxacin	Piperazinyl
Lomefloxacin	Piperazinyl
Norfloxacin	Piperazinyl
Fleroxacin	Piperazinyl
Ofloxacin	Piperazinyl
Sparfloxacin	Piperazinyl
Grepafloxacin	Piperazinyl
Gatafloxacin	Piperazinyl
Levofloxacin	Piperazinyl
Clinafloxacin	Pyrrolidinyl
Nadifloxacin	Pyrrolidinyl
Sitafloxacin	Pyrrolidinyl
Irloxacin	Pyrryl
Balofloxacin	Piperidinyl
Substituted at position 8
Sparfloxacin	F
Lomefloxacin	F
Fleroxacin	F
Ciprofloxacin	CH₂
Temafloxacin	CH₂
Pefloxacin	CH₂
Norfloxacin	CH₂
Grepafloxacin	CH₂
Clinafloxacin	Cl
Sitafloxacin	Cl
Enoxacin	N
Tosufloxacin	N
Gemifloxacin	N
Trovafloxacin	N
Ecenofloxacin	N
Alatrofloxacin	N
Gatifloxacin	Methoxy
Pazufloxacin	Methoxy
Balofloxacin	Methoxy
Moxifloxacin	Methoxy
Garenoxacin	Methoxy
Tricyclic derivatives
Abufloxacin
Droxacin
Flumequine
Levofloxacin
Marbofloxacin
Miloxacin
Ofloxacin
Oxolinic acid
Pazufloxacin
Prulifloxacin
Rufloxacin
Verbafloxacin

Sparfloxacin, the third generation drug of the quinolone antibiotics, is the virus reverse transcriptase inhibitor.

CLINICAL APPLICATIONS;
-Uncomplicated urinary tract infections
-Complicated urinary tract infections
-Pyelonephritis
-sexually transmitted diseases
-prostatitis
-skin and tissue infections
-Urethral and cervical gonococcal infections
-Acute exacerbations of chronic bronchitis
-community-acquired pneumonia

SALES SPECIFICATION

APPEARANCE

off-white to yellow crystals

ASSAY

98.0% min

BIBLIOGRAPHY

USP 24

TRANSPORTATION

PACKING

25kgs in fiber drum

HAZARD CLASS

UN NO.

OTHER INFORMATION

Hazard Symbols: n/a, Risk Phrases: 42/43, Safety Phrases:22-36/37-45

PRICE INFORMATION