| CAS
NO. |
111025-46-8
(Base)
112529-15-4 (HCl) |
|
| EINECS NO. |
|
| FORMULA |
C19H20N2O3S·HCl |
| MOL
WT. |
392.90 |
|
H.S.
CODE
|
|
|
TOXICITY
|
|
| SYNONYMS |
Pioglitazone hydrochloride;
|
|
5-[4-[2-(5-Ethyl-2-pyridinyl)
ethoxy] benzyl] thiazolidine-2,4-dione, Hydrochloride;
Actos; 5-(p-(2-(5-Ethyl-2-pyridyl)ethoxy)benzyl)-2,4-thiazolidinedione
monohydrochloride; Other CAS RN:
105355-27-9;
198077-89-3; |
|
DERIVATION |
|
|
CLASSIFICATION
|
HYPOGLYCEMIC AGENTS
/ |
|
PHYSICAL AND CHEMICAL PROPERTIES
|
| PHYSICAL
STATE |
white
to off-white crystalline
powder |
| MELTING POINT |
188 - 192 C |
| BOILING
POINT |
|
| SPECIFIC GRAVITY |
|
| SOLUBILITY
IN WATER |
Insoluble (soluble
in DMF, DMSO) |
| pH |
|
| VAPOR DENSITY |
|
|
AUTOIGNITION
|
|
|
NFPA
RATINGS
|
|
|
REFRACTIVE
INDEX
|
|
| FLASH
POINT |
|
| STABILITY |
Stable
under ordinary conditions. |
|
GENERAL
DESCRIPTION & APPLICATIONS
|
|
Pioglitazone,
belongs to the drug class of thiazolidinedione, is used to decrease insulin resistance. It is an antidiabetic agent
to manage a certain type of diabetes like NIDDM (non-insulin-dependent diabetes
mellitus, sugar diabetes) called type 2 diabetes. It improves glycemic control
while reducing circulating insulin levels. Its chemical designation is
5-[4-[2-(5-Ethyl-2-pyridinyl) ethoxy] benzyl] thiazolidine-2,4-dione. There are two
enantiomers of pioglitazone but no differences were found in their activities.
Thus, the racemic mixture is used in the pharmacologic. The hydrochloride salt
of pioglitazone is a white crystalline powder with no odur; administered orally;
insoluble in water and ether; slightly soluble in acetone, acetonitrile and
alcohol; soluble in DMF and DMSO.
Antidiabetics include:
- Sulfonylureas
- Chlorpropamide
(CAS#: 94-20-2)
- Tolbutamide
(CAS#: 64-77-7)
- Tolazamide
(CAS#: 1156-19-0)
- Glipizide
(CAS#:
29094-61-9)
- Glyburide
(CAS#:
10238-21-8)
- Gliclazide
(CAS#:
21187-98-4)
- Glibenclamide
(CAS#:
10238-21-8)
- Glimepiride
(CAS#: 93479-97-1)
- Gliquidone
(CAS#:
33342-05-1)
- Meglitinide
analogues
- Repaglinide
(CAS#:
135062-02-1)
- Nateglinide
(CAS#: 105816-04-4)
- Meglitinide (CAS#: 54870-28-9)
- Mitiglinide
(CAS#: 145375-43-5)
- Mitiglinide
Calcium (CAS #: 145525-41-3)
- Biguanide
- Metformin
(CAS#: 657-24-9)
- Phenformin
(CAS#:
114-86-3)
- Thiazolidinediones
(Glitazones)
- Rosiglitazone
(CAS#: 155141-29-0)
- Pioglitazone
(CAS#:
111025-46-8)
- Alpha-glucosidase Inhibitors
- Acarbose
(CAS#:
56180-94-0)
- Miglitol
(CAS#:
72432-03-2)
- Dipeptidylpeptidase IV inhibitor
- Saxagliptin
(CAS#: 361442-04-8)
- Sitagliptin
(CAS#: 790712-60-6)
- Vildagliptin
(CAS#: 274901-16-5)
|
| SALES
SPECIFICATION (USP24) |
|
APPEARANCE
|
white
to off-white crystalline
powder |
|
ASSAY
(HPLC) |
98.5%
- 101.5% |
|
MELTING
POINT
|
188-
193 C
|
|
LOSS
ON DRYING
|
0.5%
max
|
|
RESIDUE
ON IGNITION
|
0.2%
max
|
|
TOTAL
IMPURITY
|
1.5%
max
|
|
HEAVY METALS |
20ppm
max
|
| TRANSPORTATION |
| PACKING |
|
| HAZARD CLASS |
|
| UN
NO. |
|
| OTHER
INFORMATION |
|
Hazard Symbols: , Risk Phrases: , Safety Phrases: 22-24/25 |
|
PRICE |
|
|
