PIOGLITAZONE HCl

PRODUCT IDENTIFICATION
CAS NO. 111025-46-8 (Base)
112529-15-4 (HCl)

PIOGLITAZONE

EINECS NO.  
FORMULA C19H20N2O3S·HCl
MOL WT. 392.90

H.S. CODE

  

TOXICITY

  
SYNONYMS Pioglitazone hydrochloride;
5-[4-[2-(5-Ethyl-2-pyridinyl) ethoxy] benzyl] thiazolidine-2,4-dione, Hydrochloride; Actos; 5-(p-(2-(5-Ethyl-2-pyridyl)ethoxy)benzyl)-2,4-thiazolidinedione monohydrochloride; Other CAS RN: 105355-27-9; 198077-89-3;
DERIVATION

 

CLASSIFICATION

 HYPOGLYCEMIC AGENTS /

PHYSICAL AND CHEMICAL PROPERTIES
PHYSICAL STATE white to off-white crystalline powder
MELTING POINT 188 - 192 C
BOILING POINT  
SPECIFIC GRAVITY  
SOLUBILITY IN WATER Insoluble (soluble in DMF, DMSO)
pH  
VAPOR DENSITY

 

AUTOIGNITION

 

NFPA RATINGS

  

REFRACTIVE INDEX

  
FLASH POINT

 

STABILITY Stable under ordinary conditions.

GENERAL DESCRIPTION & APPLICATIONS
Pioglitazone, belongs to the drug class of thiazolidinedione, is used to decrease insulin resistance. It is an antidiabetic agent to manage  a certain type of diabetes like NIDDM (non-insulin-dependent diabetes mellitus, sugar diabetes) called type 2 diabetes. It improves glycemic control while reducing circulating insulin levels. Its chemical designation is 5-[4-[2-(5-Ethyl-2-pyridinyl) ethoxy] benzyl] thiazolidine-2,4-dione. There are two enantiomers of pioglitazone but no differences were found in their activities. Thus, the racemic mixture is used in the pharmacologic. The hydrochloride salt of pioglitazone is a white crystalline powder with no odur; administered orally; insoluble in water and ether; slightly soluble in acetone, acetonitrile and alcohol; soluble in DMF and DMSO.

Antidiabetics include:

  • Sulfonylureas
    • Chlorpropamide (CAS#: 94-20-2)
    • Tolbutamide (CAS#: 64-77-7)
    • Tolazamide (CAS#: 1156-19-0)
    • Glipizide (CAS#: 29094-61-9)
    • Glyburide (CAS#: 10238-21-8)
    • Gliclazide (CAS#: 21187-98-4)
    • Glibenclamide (CAS#: 10238-21-8)
    • Glimepiride (CAS#: 93479-97-1)
    • Gliquidone (CAS#: 33342-05-1)
  • Meglitinide analogues
    • Repaglinide (CAS#: 135062-02-1)
    • Nateglinide (CAS#: 105816-04-4)
    • Meglitinide (CAS#: 54870-28-9)
    • Mitiglinide (CAS#: 145375-43-5)
    • Mitiglinide Calcium (CAS #: 145525-41-3)
  • Biguanide
    • Metformin (CAS#: 657-24-9)
    • Phenformin (CAS#: 114-86-3)
  • Thiazolidinediones (Glitazones)
    • Rosiglitazone (CAS#: 155141-29-0)
    • Pioglitazone (CAS#: 111025-46-8)
  • Alpha-glucosidase Inhibitors
    • Acarbose (CAS#: 56180-94-0)
    • Miglitol (CAS#: 72432-03-2)
  • Dipeptidylpeptidase IV inhibitor
    • Saxagliptin (CAS#: 361442-04-8)
    • Sitagliptin (CAS#: 790712-60-6)
    • Vildagliptin (CAS#: 274901-16-5)
SALES SPECIFICATION (USP24)

APPEARANCE

 white to off-white crystalline powder

ASSAY (HPLC)

 98.5% - 101.5%

MELTING POINT

188- 193 C

LOSS ON DRYING

0.5% max

RESIDUE ON IGNITION

0.2% max

TOTAL IMPURITY

1.5% max
HEAVY METALS

20ppm max
TRANSPORTATION
PACKING

 

HAZARD CLASS  
UN NO.  
OTHER INFORMATION
Hazard Symbols: , Risk Phrases: , Safety Phrases: 22-24/25