N-ACETYLNEURAMINIC ACID

PRODUCT IDENTIFICATION
CAS NO. 131-48-6

N-ACETYLNEURAMINIC ACID
EINECS NO. 205-023-1
FORMULA C11H19NO9
MOL WT. 309.27

H.S. CODE

  

TOXICITY

  
SYNONYMS Lactaminic acid; NANA;
o-Sialic acid; 5-Acetamido-3,5-dideoxy-D-glycero-D-galacto-2-nonulosonic acid; 5-Acetamido-3,5-dideoxy-D-glycero-D-galactonulosonic acid; Aceneuramic acid; Neu5Ac; Neu5Ac; sialic acid; ácido N-acetilneuramínico; Acide N-acétylneuraminique; Aceneuramic acid;
DERIVATION

 

CLASSIFICATION

  

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE white to off-white powder
MELTING POINT 186 C
BOILING POINT  
SPECIFIC GRAVITY  
SOLUBILITY IN WATER  
pH  
VAPOR DENSITY

 
AUTOIGNITION

 
NFPA RATINGS  

REFRACTIVE INDEX

  
FLASH POINT

 
STABILITY

Stable under ordinary conditions. Hygroscopic.

GENERAL DESCRIPTION & APPLICATIONS
Neuraminic acid, a C-9 amino sugar, is the aldol condensation compound of pyruvic acid and N-acetyl-D-mannosamine. Its nitrogen- and oxygen-substituted N-acyl derivatives called sialic acids are important in nature. Sialic acids are found as the terminal sugar of cell surface glycoproteins. They are widely distributed in bacteria and in animal tissue including blood cells. Sialic acids are components of lipids, polysaccharides, and mucoproteins, as cell surface glycoproteins that roles in cell adhesion, recognition, and interaction. N-Acetylneuraminic acid ( also called sialic acid or 'NANA' or 'SA' or Neu5Ac) is a white to off-white powder; melting point 185 - 187 C; soluble in water; insoluble in ether; unstable in strong acid and alkali. Ganglioside is any of a group of glycosphingolipids containing one or more sialic acids (N-acyl fatty acid derivative of sphingosine such as N-acetylglucosamine or N-acetylgalactosamine, and N-acetylneuraminic acid) linked to a carbohydrate (glucose or galactose). The basic structure is ceramide-glucose-galactose-N-acetylneuraminic acid. Ganglioside is found in neuronal surface membranes and spleen. It is a component the cell plasma membrane which modulates cell signal transduction activity. It is also considered to be involved in immunology. In the Svennerholm system abbrevations, gangliosides are designated G for ganglioside, plus subscript M, D, or T for mono-, di-, or trisialo, respectively, the subscript letter being followed by a subscript arabic numeral to indicated sequence of migration in thin-layer chromatograms. The main gangliosides of the brain are GM1, GD1a, GD1b and GT1. GM3 is present mainly outside brain tissues. Natural and semisynthetic gangliosides are considered possible therapeutics for neurodegenerative disorders.

Members of neuraminic acid

Product

CAS RN
Neuraminic acid 114-04-5
Aceneuramic acid 131-48-6
(-)-N-Acetylneuraminic acid, synthetic 489-46-3
3-Fluoro-N-acetylneuraminic acid 921-40-4
N-Glycolylneuraminic acid 1113-83-3
Cytidine monophosphate N-acetylneuraminic acid 3063-71-6
Neuraminidase 9001-67-6
N-Acetylneuraminic acid aldolase 9027-60-5
4-O-Acetyl-N-acetylneuraminic acid 16655-75-7
8-O-Acetyl-N-acetylneuraminic acid 18529-64-1
N-Acetylneuraminoyllactose sulfate ester 22352-48-3
5-N-Acetyl-2-O-(3-methoxyphenyl)-alpha-D-neuraminic acid 24751-40-4
2-Deoxy-2,3-dehydro-N-acetylneuraminic acid 24967-27-9
2-O-(4-Nitrophenyl)-N-acetylneuraminic acid 26112-88-9
N-Acetyl-2-(3-methoxyphenyl)neuraminic acid 30804-44-5
N-Acetylneuraminyl-(2-6)-galactose 35259-23-5
N-Acetylneuraminoyllactose 35890-38-1
2-Deoxy-2,3-didehydro-N-glycoloylneuraminic acid 39937-91-2
2,3-Dehydroneuraminic acid 41976-42-5
2-O-Methyl-4,7,8,9-tetra-O-acetyl-N-acetyl-alpha-D-neuraminic acid 50669-91-5
4-O-Acetyl-alpha-N-acetylneuraminyl-(2-3)-lactose 53248-77-4
9-O-Acetyl-N-acetylneuraminic acid 55717-54-9
2-Methoxyneuraminic acid 56144-08-2
N-Acetyl-9-O-lactylneuraminic acid 58718-38-0
Polysialoganglioside 59247-13-1
2'-(4-Methylumbelliferyl)-alpha-D-N-acetylneuraminic acid 59322-44-0
Disialyl-N-tetraose 61278-38-4
Disialosyllactosylceramide 62010-37-1
Neuraminin 63346-33-8
5-N-Acetylneuraminic acid-5-bromo-3-indolyl-alpha-ketoside 64122-65-2
N-Acetylneuraminosyl(alpha2-6)lactosamine 64364-50-7
Neuramin lactitol 65907-88-2
4-O-Methyl-N-acetylneuraminic acid 67974-39-4
N-Glycolylneuraminyllactosylceramide 69345-49-9
Ganglio-N-tetraosylceramide 71012-19-6
Disialosyl galactosyl globoside 71764-07-3
2-6-N-Acetylneuraminyl-1-4-galactosyl-1-3-N-acetylglucosyl-1-4-galactosyl-1- glucosylceramide 71833-54-0
Sialosyllactosaminylparagloboside 71833-58-4
Sialosylparagloboside 71833-57-3
IV(4)-Galactosyl-N-acetylganglioside GD1a 72429-69-7
N-Glycosylsialoparagloboside 72626-26-7
4-O-Acetyl-N-glycolylneuraminyl lactosylceramide 73379-75-6
2'-(4-Methylumbelliferyl)-alpha-D-N-acetylneuraminic acid sodium salt hydrate 76204-02-9
Ganglioside T1 76688-83-0
Ganglioside M5 77322-99-7
N-Acetylneuraminosyl lacto-N-noroctaosyl ceramide 77700-05-1
2,3-Dehydro-4-epi-N-acetylneuraminic acid 79026-37-2
5-Fluoro-2',3'-isopropylidene-5'-O-(4-N-acetyl-2,4-dideoxy-3,6,7,8-tetra-O-acetyl-1- methoxycarbonylglycerogalactooctapyranosyl)uridine 80681-73-8
Poly((2-9)-alpha-N-acetylneuraminic acid) 82803-97-2
2-(N-3'-Sialyllactityl)aminopyridine 83073-74-9
N-Acetylneuraminyl-(2-3)-galactose 83563-61-5
Disialosyl paragloboside 83713-05-7
Streptococcal polysaccharide Ib group B 84280-27-3
Streptococcal polysaccharide Ia group B 84280-28-4
2-(N-6'-Sialyllactityl)aminopyridine 85179-36-8
G(M1)-Oligosaccharide 85373-04-2
N-Acetyl-9-deoxy-9-fluoroneuraminic acid 85819-28-9
Sialosylgloboside 86168-20-9
GM2 N-Glycolylneuraminic acid ganglioside 88528-32-9
Di-(N-glycolylneuraminic acid)ganglioside GD1b 91594-08-0
Sodium N-acetylneuraminate 92413-99-5
9-O-Lactoyl-N-acetylneuraminic acid 92935-30-3
Disialo-lacto-N-norhexaosyl ceramide 95507-88-3
2,7-Anhydro-N-acetylneuraminic acid 95574-95-1
2-3-N-Acetylneuraminyl-1-3-galactosyl-1-3-N-acetylglucosyl-1-4-galactosyl-1- glucosylceramide 97047-95-5
O-(N-Acetyl-alpha-neuraminosyl)-(2.3)-O-beta-D-galactopyranosyl-(1.4)-alpha-D- glucopyranose ammonium salt 97416-76-7
Ganglioside NGM 1 97708-84-4
Cytidine monophosphate-N-glycoloylneuraminic acid 98300-80-2
Siagoside 100345-64-0
Disialosylneolactotetraosylceramide 100365-94-4
Sialyl-fucosyl-lacto-N-norhexaosylceramide 101359-93-7
Ganglioside GD1alpha 101839-44-5
Ganglioside M1 lactone 103220-36-6
IV(3)-Neuac-lcose4Cer 103842-51-9
5-(Acetylamino)-3,5-dideoxy-D-glycero-beta-D-galacto-2-nonulopyranosonic acid potassium salt 103882-92-4
5-(Acetylamino)-3,5-dideoxy-D-glycero-beta-D-galacto-2-nonulopyranosonic acid lithium salt 103882-91-3
Lactoisooctaosylceramide 104042-02-6
Disialosyl Le(a) 104220-70-4
4,8-Anhydro-N-acetylneuraminic acid 109915-63-1
N-Acetylneuraminyl cholesterol 113108-90-0
3-O-(2-Acetamido-6-O-(N-acetylneuraminyl)-2-deoxygalactosyl)serine 114661-01-7
5-(Acetylamino)-3,5-dideoxy-D-glycero-beta-D-galacto-2-nonulopyranosonic acid magnesium salt 114767-12-3
5-(Acetylamino)-3,5-dideoxy-D-glycero-beta-D-galacto-2-nonulopyranosonic acid barium salt 114767-11-2
De-N-acetylneuraminyllactosylceramide 115082-64-9

Methyl 4,7,8,9-tetra-O-acetyl-2-thio-N-acetyl-alpha-D-neuraminic acid methyl ester

116450-06-7
b-Neuraminic acid, N-acetyl-2-O-methyl-, 1,7-lactone, 4,8,9-triacetate 116897-96-2
12-((4-Azido-2-nitrophenyl)amino)dodecanoyl-GM1 116926-94-4
N-Acetyl-4,7-dideoxyneuraminic acid 117193-44-9
N-Acetyl-9-deoxyneuraminic acid 117193-36-9
N-Acetyl-7-deoxyneuraminic acid 117193-31-4
N-Acetyl-8-deoxyneuraminic acid 117247-24-2
Sialyl-Le(a) oligosaccharide 117978-16-2
GD3 Lactone II 119912-76-4
GD3 Lactone I 119912-77-5
N-Parinaroylganglioside G(M1) 120418-73-7
(N-Acetylneuraminosyl-(2-8)-N-glycolylneuraminic acid)gangliotetraosylceramide 121382-26-1
N-Acetylneuraminyl(2-3)galactosyl(1-3)-N-acetylglucosyl(1-6)-N-acetylgalactose 122137-12-6
Sialyl-alpha2-6-mannosyl-beta1-4-N-acetylglucosamine 125366-24-7
9-O-Acetyl-2-keto-3-deoxyglycero-galacto-nononic acid 126265-01-8
Liga 20 126586-85-4
HB-6 Antigen 126649-90-9
N-Acetyl-4-deoxy-4-acetamidoneuraminic acid 127099-59-6
O-Acetyldisialosyl paragloboside 128543-21-5
N-Acetylneuraminic acid methyl glycoside 128643-78-7
8-O-Methyl-7,9-di-O-acetyl-N-glycolylneuraminic acid 128885-13-2
Ganglioside GM4-1 129069-16-5
5-N-Acetyl-9-(4-azidosalicoylamido)-2-deoxy-2,3-didehydroneuraminic acid 129178-63-8
Lactosaminyl-G(M1) 129898-66-4
N-Acetyl-2-deoxy-2,3-difluoroneuraminic acid 129932-88-3
N-Acetyl-3-fluoroneuraminic acid 129950-58-9
4-Amino-2-deoxy-2,3-didehydro-N-acetylneuraminic acid 130525-62-1
Mipragoside 131129-98-1
Streptococcal polysaccharide V group B 134366-06-6
CMP-deaminoneuraminic acid 137463-62-8
Zanamivir 139110-80-8
GT1aalpha Ganglioside 141255-28-9
2-(N-Dansyl-4-aminophenylthio)-N-acetyl-9-O-acetylneuraminic acid 141303-70-0
GQ1balpha Ganglioside 143476-26-0
N-Acetyl-9-O-acetylneuraminic acid 4-aminophenylthioketoside 146117-12-6
IV(3)-Neuac-III(6)-neuac-lcose4Cer 146358-72-7
N-Acetylneuraminyl-2-6-galactopyranosyl-1-4-N-acetylglucosaminyl-1-O-pent-4-ene 151960-90-6
De-N-acetyllysoGM1 152784-11-7
Gangliosides

 
SALES SPECIFICATION

APPEARANCE

 white to off-white powder

PURITY (G.C.)

98.0% min

OPTICAL ROTATION

-30° ~ -34°
TRANSPORTATION
PACKING
 
HAZARD CLASS  
UN NO.  
OTHER INFORMATION
Hazard Symbols: , Risk Phrases: , Safety Phrases: 22-24/25
Other CAS RN: 5977-25-3; 6225-16-7; 6918-20-3; 11032-36-3; 14752-56-8