| N-ACETYLNEURAMINIC ACID | |||
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PRODUCT IDENTIFICATION |
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| CAS NO. | 131-48-6 |
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| EINECS NO. | 205-023-1 | ||
| FORMULA | C11H19NO9 | ||
| MOL WT. | 309.27 | ||
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H.S. CODE |
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TOXICITY |
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| SYNONYMS | Lactaminic acid; NANA; | ||
| o-Sialic acid; 5-Acetamido-3,5-dideoxy-D-glycero-D-galacto-2-nonulosonic acid; 5-Acetamido-3,5-dideoxy-D-glycero-D-galactonulosonic acid; Aceneuramic acid; Neu5Ac; Neu5Ac; sialic acid; ácido N-acetilneuramínico; Acide N-acétylneuraminique; Aceneuramic acid; | |||
| DERIVATION |
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CLASSIFICATION |
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PHYSICAL AND CHEMICAL PROPERTIES |
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| PHYSICAL STATE | white to off-white powder | ||
| MELTING POINT | 186 C | ||
| BOILING POINT | |||
| SPECIFIC GRAVITY | |||
| SOLUBILITY IN WATER | |||
| pH | |||
| VAPOR DENSITY |
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| AUTOIGNITION |
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| NFPA RATINGS | |||
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REFRACTIVE INDEX |
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| FLASH POINT |
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| STABILITY |
Stable under ordinary conditions. Hygroscopic. |
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GENERAL DESCRIPTION & APPLICATIONS |
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| Neuraminic acid, a C-9 amino sugar, is the aldol condensation compound of
pyruvic acid and N-acetyl-D-mannosamine. Its nitrogen- and
oxygen-substituted N-acyl derivatives called sialic acids are important in nature.
Sialic acids are found as the
terminal sugar of cell surface glycoproteins. They are widely distributed in bacteria and
in animal tissue including blood cells. Sialic acids are components of lipids, polysaccharides, and
mucoproteins, as cell surface glycoproteins that roles in cell adhesion,
recognition, and interaction. N-Acetylneuraminic acid ( also called sialic acid or 'NANA' or 'SA' or Neu5Ac)
is a white to off-white powder; melting point 185 -
187 C; soluble in water; insoluble in ether; unstable
in strong acid and alkali. Ganglioside is any of a group of glycosphingolipids containing
one or more sialic acids (N-acyl fatty acid
derivative of sphingosine such as N-acetylglucosamine or N-acetylgalactosamine, and
N-acetylneuraminic acid) linked to a carbohydrate (glucose or galactose). The basic structure is
ceramide-glucose-galactose-N-acetylneuraminic acid.
Ganglioside is found in neuronal
surface membranes and spleen. It is a component the cell plasma membrane which modulates cell signal transduction
activity. It is also considered to be involved in immunology. In
the Svennerholm system abbrevations, gangliosides are designated G for ganglioside, plus subscript M,
D, or T for mono-, di-, or trisialo, respectively, the subscript letter being
followed by a subscript arabic numeral to indicated sequence of migration in
thin-layer chromatograms. The main gangliosides of the brain are GM1, GD1a, GD1b
and GT1. GM3 is present mainly outside brain tissues. Natural and semisynthetic gangliosides
are considered possible therapeutics for neurodegenerative disorders.
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| SALES SPECIFICATION | |||
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APPEARANCE |
white to off-white powder | ||
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PURITY (G.C.) |
98.0% min |
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OPTICAL ROTATION |
-30° ~ -34° |
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| TRANSPORTATION | |||
| PACKING |
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| HAZARD CLASS | |||
| UN NO. | |||
| OTHER INFORMATION | |||
| Hazard Symbols: , Risk Phrases: , Safety
Phrases: 22-24/25 Other CAS RN: 5977-25-3; 6225-16-7; 6918-20-3; 11032-36-3; 14752-56-8 |
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| PRICE | |||
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Product |
CAS RN |
| Neuraminic acid | 114-04-5 |
| Aceneuramic acid | 131-48-6 |
| (-)-N-Acetylneuraminic acid, synthetic | 489-46-3 |
| 3-Fluoro-N-acetylneuraminic acid | 921-40-4 |
| N-Glycolylneuraminic acid | 1113-83-3 |
| Cytidine monophosphate N-acetylneuraminic acid | 3063-71-6 |
| N-Acetylneuraminic acid 2,4,7,8,9-pentaacetate | 4887-11-0 |
| Neuraminidase | 9001-67-6 |
| N-Acetylneuraminic acid aldolase | 9027-60-5 |
| Disialoganglioside GD1a | 12707-58-3 |
| 2-O-(2-Nitrophenyl)-alpha-D-N-acetylneuraminic acid | 15707-92-1 |
| 2-O-Phenyl alpha--D-N-acetylneuraminic acid | 15964-32-6 |
| 4-O-Acetyl-N-acetylneuraminic acid | 16655-75-7 |
| 8-O-Acetyl-N-acetylneuraminic acid | 18529-64-1 |
| Disialoganglioside GD1b | 19553-76-5 |
| N-Acetylneuraminoyllactose sulfate ester | 22352-48-3 |
| 2-O-Methyl-beta-D-N-acetylneuraminic acid | 23755-35-3 |
| 5-N-Acetyl-2-O-(3-methoxyphenyl)-alpha-D-neuraminic acid | 24751-40-4 |
| 2-Deoxy-2,3-dehydro-N-acetylneuraminic acid | 24967-27-9 |
| N-Acetyl-2,3-dehydro-2-deoxyneuraminic acid methyl ester | 25875-99-4 |
| 2-O-(4-Nitrophenyl)-N-acetylneuraminic acid | 26112-88-9 |
| N-Acetyl-2-(3-methoxyphenyl)neuraminic acid | 30804-44-5 |
| N-Acetylneuraminyl-(2-6)-galactose | 35259-23-5 |
| N-Acetylneuraminoyllactose | 35890-38-1 |
| Monosialoganglioside GM1 | 37758-47-7 |
| 2-Deoxy-2,3-didehydro-N-glycoloylneuraminic acid | 39937-91-2 |
| 2,3-Dehydroneuraminic acid | 41976-42-5 |
| 2-O-Methyl-4,7,8,9-tetra-O-acetyl-N-acetyl-alpha-D-neuraminic acid | 50669-91-5 |
| 2-O-Methyl-a-D-N-acetylneuraminic acid | 50930-22-8 |
|
N-Acetylneuraminic acid |
50998-13-5 |
| 4-O-Acetyl-alpha-N-acetylneuraminyl-(2-3)-lactose | 53248-77-4 |
| 9-O-Acetyl-N-acetylneuraminic acid | 55717-54-9 |
| 2-Methoxyneuraminic acid | 56144-08-2 |
| N-Acetyl-9-O-lactylneuraminic acid | 58718-38-0 |
| Polysialoganglioside | 59247-13-1 |
| Trisialoganglioside GT1b | 59247-13-1 |
| 2'-(4-Methylumbelliferyl)-alpha-D-N-acetylneuraminic acid | 59322-44-0 |
| 4-Methylumbelliferyl alpha-D-N-acetyl-4,7,8,9-tetra-O-acetylneuraminic acid methyl ester | 59361-08-9 |
| Disialyl-N-tetraose | 61278-38-4 |
| Disialosyllactosylceramide | 62010-37-1 |
| Disialoganglioside GD3 | 62010-37-1 |
| Neuraminin | 63346-33-8 |
| 5-N-Acetylneuraminic acid-5-bromo-3-indolyl-alpha-ketoside | 64122-65-2 |
| N-Acetylneuraminosyl(alpha2-6)lactosamine | 64364-50-7 |
| Neuramin lactitol | 65907-88-2 |
| Disialoganglioside-GD2 | 65988-71-8 |
| 4-O-Methyl-N-acetylneuraminic acid | 67974-39-4 |
| N-Glycolylneuraminyllactosylceramide | 69345-49-9 |
| Asialo-Gm1-ganglioside | 71012-19-2 |
| Ganglio-N-tetraosylceramide | 71012-19-6 |
| Disialosyl galactosyl globoside | 71764-07-3 |
| Sialosyllactosaminylparagloboside | 71833-58-4 |
| Sialosylparagloboside | 71833-57-3 |
| 2-6-N-Acetylneuraminyl-1-4-galactosyl-1-3-N-acetylglucosyl-1-4-galactosyl-1- glucosylceramide | 71833-54-0 |
| IV(4)-Galactosyl-N-acetylganglioside GD1a | 72429-69-7 |
| N-Glycosylsialoparagloboside | 72626-26-7 |
| 4-O-Acetyl-N-glycolylneuraminyl lactosylceramide | 73379-75-6 |
N-Acetyl-2,3-didehydro-4,7,8,9-tetra-O-acetyl-D-neuraminic acid |
73960-72-2 |
| 2'-(4-Methylumbelliferyl)-alpha-D-N-acetylneuraminic acid sodium salt hydrate | 76204-02-9 |
| Ganglioside T1 | 76688-83-0 |
| Ganglioside M5 | 77322-99-7 |
| N-Acetylneuraminosyl lacto-N-noroctaosyl ceramide | 77700-05-1 |
| 2,3-Dehydro-4-epi-N-acetylneuraminic acid | 79026-37-2 |
| 5-Fluoro-2',3'-isopropylidene-5'-O-(4-N-acetyl-2,4-dideoxy-3,6,7,8-tetra-O-acetyl-1- methoxycarbonylglyceroga lactooctapyranosyl)uridine | 80681-73-8 |
| Poly((2-9)-alpha-N-acetylneuraminic acid) | 82803-97-2 |
| 2-(N-3'-Sialyllactityl)aminopyridine | 83073-74-9 |
| N-Acetylneuraminyl-(2-3)-galactose | 83563-61-5 |
| Disialosyl paragloboside | 83713-05-7 |
| Streptococcal polysaccharide Ib group B | 84280-27-3 |
| Streptococcal polysaccharide Ia group B | 84280-28-4 |
| N-Acetylneuraminic Acid Methyl Ester 4,7,8,9-tetraacetate | 84380-10-9 |
| 2-(N-6'-Sialyllactityl)aminopyridine | 85179-36-8 |
| G(M1)-Oligosaccharide | 85373-04-2 |
| N-Acetyl-9-deoxy-9-fluoroneuraminic acid | 85819-28-9 |
| Sialosylgloboside | 86168-20-9 |
| GM2 N-Glycolylneuraminic acid ganglioside | 88528-32-9 |
| Di-(N-glycolylneuraminic acid)ganglioside GD1b | 91594-08-0 |
| Sodium N-acetylneuraminate | 92413-99-5 |
| 9-O-Lactoyl-N-acetylneuraminic acid | 92935-30-3 |
| Disialo-lacto-N-norhexaosyl ceramide | 95507-88-3 |
| 2,7-Anhydro-N-acetylneuraminic acid | 95574-95-1 |
| 2-3-N-Acetylneuraminyl-1-3-galactosyl-1-3-N-acetylglucosyl-1-4-galactosyl-1- glucosylceramide | 97047-95-5 |
| O-(N-Acetyl-alpha-neuraminosyl)-(2.3)-O-beta-D-galactopyranosyl-(1.4)-alpha-D- glucopyranose ammonium salt | 97416-76-7 |
| Ganglioside NGM 1 | 97708-84-4 |
| Cytidine monophosphate-N-glycoloylneuraminic acid | 98300-80-2 |
| Siagoside | 100345-64-0 |
| Disialosylneolactotetraosylceramide | 100365-94-4 |
| Sialyl-fucosyl-lacto-N-norhexaosylceramide | 101359-93-7 |
| Ganglioside GD1alpha | 101839-44-5 |
| Ganglioside M1 lactone | 103220-36-6 |
| IV(3)-Neuac-lcose4Cer | 103842-51-9 |
| 5-(Acetylamino)-3,5-dideoxy-D-glycero-beta-D-galacto-2-nonulopyranosonic acid lithium salt | 103882-91-3 |
| 5-(Acetylamino)-3,5-dideoxy-D-glycero-beta-D-galacto-2-nonulopyranosonic acid potassium salt | 103882-92-4 |
| Lactoisooctaosylceramide | 104042-02-6 |
| Disialosyl Le(a) | 104220-70-4 |
| 4,8-Anhydro-N-acetylneuraminic acid | 109915-63-1 |
| N-Acetylneuraminyl cholesterol | 113108-90-0 |
| 3-O-(2-Acetamido-6-O-(N-acetylneuraminyl)-2-deoxygalactosyl)serine | 114661-01-7 |
| 5-(Acetylamino)-3,5-dideoxy-D-glycero-beta-D-galacto-2-nonulopyranosonic acid magnesium salt | 114767-12-3 |
| 5-(Acetylamino)-3,5-dideoxy-D-glycero-beta-D-galacto-2-nonulopyranosonic acid barium salt | 114767-11-2 |
| De-N-acetylneuraminyllactosylceramide | 115082-64-9 |
|
Methyl 4,7,8,9-tetra-O-acetyl-2-thio-N-acetyl-alpha-D-neuraminic acid methyl ester |
116450-06-7 |
| b-Neuraminic acid, N-acetyl-2-O-methyl-, 1,7-lactone, 4,8,9-triacetate | 116897-96-2 |
| 12-((4-Azido-2-nitrophenyl)amino)dodecanoyl-GM1 | 116926-94-4 |
| N-Acetyl-4,7-dideoxyneuraminic acid | 117193-44-9 |
| N-Acetyl-7-deoxyneuraminic acid | 117193-31-4 |
| N-Acetyl-9-deoxyneuraminic acid | 117193-36-9 |
| N-Acetyl-8-deoxyneuraminic acid | 117247-24-2 |
| Sialyl-Le(a) oligosaccharide | 117978-16-2 |
| GD3 Lactone II | 119912-76-4 |
| GD3 Lactone I | 119912-77-5 |
| N-Parinaroylganglioside G(M1) | 120418-73-7 |
| (N-Acetylneuraminosyl-(2-8)-N-glycolylneuraminic acid)gangliotetraosylceramide | 121382-26-1 |
| N-Acetylneuraminyl(2-3)galactosyl(1-3)-N-acetylglucosyl(1-6)-N-acetylgalactose | 122137-12-6 |
| Sialyl-alpha2-6-mannosyl-beta1-4-N-acetylglucosamine | 125366-24-7 |
| 9-O-Acetyl-2-keto-3-deoxyglycero-galacto-nononic acid | 126265-01-8 |
| Liga 20 | 126586-85-4 |
| HB-6 Antigen | 126649-90-9 |
| N-Acetyl-4-deoxy-4-acetamidoneuraminic acid | 127099-59-6 |
| O-Acetyldisialosyl paragloboside | 128543-21-5 |
| N-Acetylneuraminic acid methyl glycoside | 128643-78-7 |
| 8-O-Methyl-7,9-di-O-acetyl-N-glycolylneuraminic acid | 128885-13-2 |
| Ganglioside GM4-1 | 129069-16-5 |
| 5-N-Acetyl-9-(4-azidosalicoylamido)-2-deoxy-2,3-didehydroneuraminic acid | 129178-63-8 |
| Lactosaminyl-G(M1) | 129898-66-4 |
| N-Acetyl-2-deoxy-2,3-difluoroneuraminic acid | 129932-88-3 |
| N-Acetyl-3-fluoroneuraminic acid | 129950-58-9 |
| 4-Amino-2-deoxy-2,3-didehydro-N-acetylneuraminic acid | 130525-62-1 |
| Mipragoside | 131129-98-1 |
| Streptococcal polysaccharide V group B | 134366-06-6 |
| CMP-deaminoneuraminic acid | 137463-62-8 |
| Zanamivir | 139110-80-8 |
| GT1aalpha Ganglioside | 141255-28-9 |
| 2-(N-Dansyl-4-aminophenylthio)-N-acetyl-9-O-acetylneuraminic acid | 141303-70-0 |
| GQ1balpha Ganglioside | 143476-26-0 |
| N-Acetyl-9-O-acetylneuraminic acid 4-aminophenylthioketoside | 146117-12-6 |
| IV(3)-Neuac-III(6)-neuac-lcose4Cer | 146358-72-7 |
| N-Acetylneuraminyl-2-6-galactopyranosyl-1-4-N-acetylglucosaminyl-1-O-pent-4-ene | 151960-90-6 |
| De-N-acetyllysoGM1 | 152784-11-7 |
| Phenyl 4,7,8,9-tetra-O-acetyl-2-thio-N-acetyl-D-neuraminic acid methyl ester | 155155-64-9 |
5-Bromo-4-chloro-3-indolyl-alpha-D-N-acetylneuraminic acid sodium salt |
160369-85-7 |
| N-Acetyl-2,3-dehydro-2-deoxyneuraminic acid sodium Salt | 209977-53-7 |
| Gangliosides |
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