MITIGLINIDE CALCIUM

PRODUCT IDENTIFICATION
CAS NO. 145375-43-5 (Base)
145525-41-3 (Calcium)

MITIGLINIDE CALCIUM

EINECS NO.  
FORMULA C38H48CaN2O6
MOL WT. 668.88

H.S. CODE

  

TOXICITY

  
SYNONYMS Glufast; Calcium 2-Benzyl-3-(hexahydro-2-isoindolinylcarbonyl)propionate;
(-)-(2S,3a,7a-cis)-alpha-Benzylhexahydro-gamma-oxo-2-isoindolinebutyric acid dicalcium salt dihydrate; Calcium 2-benzyl-3-(cis-hexahydro-2-isoindolinylcarbonyl)propionate dihydrate; Calcium (2S)-4-((3aS,7aR)-1,3,3a,4,5,6,7,7a-octahydroisoindol-2-yl)-2-benzyl-4-oxo-butanoate;
DERIVATION

 

CLASSIFICATION

 HYPOGLYCEMIC AGENTS /

PHYSICAL AND CHEMICAL PROPERTIES
PHYSICAL STATE white to off-white crystalline powder
MELTING POINT 146 - 148 C
BOILING POINT  
SPECIFIC GRAVITY  
SOLUBILITY IN WATER  
pH  
VAPOR DENSITY

 

AUTOIGNITION

 

NFPA RATINGS

  

REFRACTIVE INDEX

  
FLASH POINT

 

STABILITY Stable under ordinary conditions.

GENERAL DESCRIPTION & APPLICATIONS

Antidiabetics include:

  • Sulfonylureas
    • Chlorpropamide (CAS#: 94-20-2)
    • Tolbutamide (CAS#: 64-77-7)
    • Tolazamide (CAS#: 1156-19-0)
    • Glipizide (CAS#: 29094-61-9)
    • Glyburide (CAS#: 10238-21-8)
    • Gliclazide (CAS#: 21187-98-4)
    • Glibenclamide (CAS#: 10238-21-8)
    • Glimepiride (CAS#: 93479-97-1)
    • Gliquidone (CAS#: 33342-05-1)
  • Meglitinide analogues
    • Repaglinide (CAS#: 135062-02-1)
    • Nateglinide (CAS#: 105816-04-4)
    • Meglitinide (CAS#: 54870-28-9)
    • Mitiglinide (CAS#: 145375-43-5)
    • Mitiglinide Calcium (CAS #: 145525-41-3)
  • Biguanide
    • Metformin (CAS#: 657-24-9)
    • Phenformin (CAS#: 114-86-3)
  • Thiazolidinediones (Glitazones)
    • Rosiglitazone (CAS#: 155141-29-0)
    • Pioglitazone (CAS#: 111025-46-8)
  • Alpha-glucosidase Inhibitors
    • Acarbose (CAS#: 56180-94-0)
    • Miglitol (CAS#: 72432-03-2)
  • Dipeptidylpeptidase IV inhibitor
    • Saxagliptin (CAS#: 361442-04-8)
    • Sitagliptin (CAS#: 790712-60-6)
    • Vildagliptin (CAS#: 274901-16-5)
 

Mitiglinide is a drug belongs to a family of meglitinide to treat diabetes type 2 by blocking the potassium channels in beta cells. It is a rapid and short-acting hypoglycemic agent which stimulate the pancreas to produce more insulin by closing the ATP-sensitive K(+) (K(ATP)) channels in pancreatic beta-cells.
SALES SPECIFICATION (USP24)

APPEARANCE

 white to off-white crystalline powder

ASSAY (HPLC)

 99.0% min

MELTING POINT

145- 145 C
TRANSPORTATION
PACKING

 

HAZARD CLASS  
UN NO.  
OTHER INFORMATION
Hazard Symbols: , Risk Phrases: , Safety Phrases: 22-24/25