| CETIRIZINE DIHYDROCHLORIDE | ||
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PRODUCT IDENTIFICATION |
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| CAS NO. | 83881-51-0
(Base) 83881-52-1 (Dihydrochloride) |
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| EINECS NO. | ||
| FORMULA | C21H23ClN2O3·2HCl | |
| MOL WT. | 461.82 | |
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H.S. CODE |
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TOXICITY |
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| SYNONYMS | (1S.2S)-2-Methylamino-1-phenyl-1-propanol dichloride; | |
| PRICE |
U$190/kg
by air (for 10kgs quantity) U$790.- by air (for 1kg quantity) |
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CLASSIFICATION |
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PHYSICAL AND CHEMICAL PROPERTIES |
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| PHYSICAL STATE | white to off-white crystalline powder | |
| MELTING POINT | ||
| BOILING POINT |
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| SPECIFIC GRAVITY |
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| SOLUBILITY IN WATER | Soluble (Insoluble in acetone ) | |
| pH | 1.2 - 1.8 (5% sol.) | |
| VAPOR DENSITY |
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AUTOIGNITION |
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NFPA RATINGS |
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REFRACTIVE INDEX |
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| FLASH POINT |
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| STABILITY |
Stable under ordinary conditions. Hygroscopic. | |
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APPLICATIONS |
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| Cetirizine is a selective H1-receptor antagonist used to treat allergic rhinitis and chronic idiopathic urticaria, and as a treatment adjunct in asthma. It is a racemic mixture of levo- and dextro-form, but levo-form is active. Chemically it is described as (1S.2S)-2-methylamino-1-phenyl-1-propanol. The hydrochloride salt of cetirizine is a white powder freely soluble in water, practically insoluble in acetone and dichloromethane; administered orally. | ||
| SALES SPECIFICATION | ||
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BIBLIOGRAPHY |
EP2000 |
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APPEARANCE |
white to off-white crystalline powder | |
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ASSAY |
99.0 - 100.5% (on dry basis) | |
| LOSS ON DRYING |
0.5% max |
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| SULFATED ASH |
0.2% max |
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HEAVY METALS |
10ppm max |
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| INDIVIDUAL IMPURITY |
0.2% max (total impurity: 0.3% max) |
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| TRANSPORTATION | ||
| PACKING | | |
| HAZARD CLASS | Not regulated | |
| UN NO. | ||
| OTHER INFORMATION | ||
