| CAS
NO. |
134523-03-8 |
|
| EINECS NO. |
|
| FORMULA |
(C33H34FN2O5)2Ca·3H2O |
| MOL
WT. |
1209.42 |
|
H.S.
CODE
|
|
|
TOXICITY
|
|
| DERIVATION |
|
| SYNONYMS |
Lipitor; |
|
(-)-Monocalcium bis[(3R, 5R)-7-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-
4-phenylcarbamoyl-1H- pyrrol-1-yl]-3,5-dihydroxyheptanoate]
Trihydrate; [R-(R',R')]-2-(4-fluorophenyl)-beta,delta-
dihydroxy-5-( 1-methylethyl)-3-phenyl-4
[(phenylamino) carbonyl]- lH-pyrrole-1-heptanoic acid, calcium salt (2:1) Trihydrate; |
|
CLASSIFICATION
|
|
|
PHYSICAL AND CHEMICAL PROPERTIES
|
| PHYSICAL
STATE |
white to
off-white crystalline
powder |
| MELTING POINT |
|
| BOILING
POINT |
|
| SPECIFIC GRAVITY |
|
| SOLUBILITY
IN WATER |
Slightly soluble |
| pH |
|
| VAPOR DENSITY |
|
|
AUTOIGNITION
|
|
|
NFPA
RATINGS
|
|
|
REFRACTIVE
INDEX
|
|
| FLASH
POINT |
|
| STABILITY |
Stable
under ordinary conditions. |
|
GENERAL
DESCRIPTION & APPLICATIONS
|
|
Atorvastatin, a synthetic cholesterol-lowering agent, is a medicine called
HMG-CoA (3 hydroxy-3-methylglutaryl-coenzyme A) reductase inhibitor. This enzyme
is involved in cholesterol biosynthesis by catalyzing the conversion reaction of
HMG-CoA to mevalonate. The fuction of lowering the amount of cholesterol leads
to the result in clearing the LDP (low-density lipoprotein) cholesterol in the
blood by increased LDL receptors. The calcium salt of atorvastatin is used in
the treatment of primary hypercholesterolema and dyslipidemia. It is a white to
off-white crystalline powder; slightly soluble in water (insoluble in aqueous
solutions of pH 4 or below); soluble in methanol, dimethyl sulfoxide; administered
orally. The chemical designation is
[R-(R',R')]-2-(4-fluorophenyl)-beta,delta-dihydroxy-5-( 1-methylethyl)-3-phenyl-4
[(phenylamino) carbonyl]- lH-pyrrole-1-heptanoic acid, calcium salt (2:1).
HMG-CoA reductase inhibitors (commonly called "statins") can be classified
in two groups.
- Semi-Synthetic
- Lovastatin (
CAS RN: 75330-75-5)
- Simvastatin
( CAS RN: 79902-63-9)
- Pravastatin Sodium (
CAS RN: 81131-70-6)
- Synthetic
- Fluvastatin
Sodium ( CAS RN: 93957-55-2)
- Atorvastatin Calcium (
CAS RN: 134523-03-8)
- Cerivastatin Sodium
( CAS RN: 143201-11-0)
- Rosuvastatin Calcium (
CAS RN: 147098-20-2)
|
| SALES
SPECIFICATION |
|
APPEARANCE
|
white to
off-white crystalline
powder |
|
IDENTIFICATION
|
Complies
(Test A,B)
|
|
ASSAY
|
98.0%
- 101.0%
|
|
CALCIUM
|
3.3%
- 3.6%
|
|
WATER
|
7.0%
max
|
|
LOSS
ON DRYING
|
0.5%
max
|
| TRANSPORTATION |
| PACKING |
|
| HAZARD CLASS |
|
| UN
NO. |
|
| OTHER
INFORMATION |
|
Hazard
Symbols: , Risk Phrases: , Safety Phrases: 22-24/25 |
|
GENERAL
DESCRIPTION OF CHOLESTEROL
|
|
Cholesterol is a steroid alcohol that is essentially insoluble in aqueous
solutions. In mammals it is normally solubilized by its association with other
lipids, such as phospholipids or bile acids; thus, most cholesterol is found in
cell membranes, plasma lipoproteins, and bile. Cholesterol can be esterified
with a fatty acid to form cholesteryl esters. The latter form discrete lipid
droplets in cells, especially in cells of steroidogenic tissues, and in the
lipid core of low-density lipoproteins in the blood. Cholesterol is a fatty lipid
sparingly insoluble in water but soluble in a number of organic solvents. It is
the most common sterol of eukaryotes which a key constituent of cell membranes
and works as the precursor of bile acids, cholecalciferol (vitamin D) and
steroid hormones including cortisol, cortisone, aldosterone and sex hormone
progesterone in vertebrates. Cholesterol is used as an emulsifying agent in
pharmaceuticals. The most cholesterols are synthesized by the liver and other tissues include the
adrenal glands and reproductive organs. Some cholesterol is absorbed from
dietary sources. The largest concentration of cholesterol is in the myelin
sheath that surrounds nerves and in the plasma membrane that surrounds all cells
in vertebrates (25% of brain lipid is cholesterol). Cholesterol can be esterified with a fatty acid to form
cholesteryl esters which form discrete lipid droplets in cells, especially in
cells of steroidogenic tissues, and in the lipid core of low-density
lipoproteins in the blood. The collection on the walls of arteries interferes
with the flow of blood. The High level of cholesterol in the blood is a major
risk factor for coronary heart diseases. |