| CAS
NO. |
134523-03-8 |
|
| EINECS NO. |
|
| FORMULA |
(C33H34FN2O5)2Ca·3H2O |
| MOL
WT. |
1209.42 |
|
H.S.
CODE
|
|
|
TOXICITY
|
|
| SYNONYMS |
Lipitor; |
|
(-)-Monocalcium bis[(3R, 5R)-7-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-
4-phenylcarbamoyl-1H- pyrrol-1-yl]-3,5-dihydroxyheptanoate]
Trihydrate; [R-(R',R')]-2-(4-fluorophenyl)-beta,delta-
dihydroxy-5-( 1-methylethyl)-3-phenyl-4
[(phenylamino) carbonyl]- lH-pyrrole-1-heptanoic acid, calcium salt (2:1) Trihydrate; |
|
CLASSIFICATION
|
|
|
PHYSICAL AND CHEMICAL PROPERTIES
|
| PHYSICAL
STATE |
white to
off-white crystalline
powder |
| MELTING POINT |
|
| BOILING
POINT |
|
| SPECIFIC GRAVITY |
|
| SOLUBILITY
IN WATER |
Slightly soluble |
| pH |
|
| VAPOR DENSITY |
|
|
AUTOIGNITION
|
|
|
NFPA
RATINGS
|
|
|
REFRACTIVE
INDEX
|
|
| FLASH
POINT |
|
| STABILITY |
Stable
under ordinary conditions. |
|
GENERAL
DESCRIPTION & APPLICATIONS
|
|
Atorvastatin, a synthetic cholesterol-lowering agent, is a medicine called
HMG-CoA (3 hydroxy-3-methylglutaryl-coenzyme A) reductase inhibitor. This enzyme
is involved in cholesterol biosynthesis by catalyzing the conversion reaction of
HMG-CoA to mevalonate. The fuction of lowering the amount of cholesterol leads
to the result in clearing the LDP (low-density lipoprotein) cholesterol in the
blood by increased LDL receptors. The calcium salt of atorvastatin is used in
the treatment of primary hypercholesterolema and dyslipidemia. It is a white to
off-white crystalline powder; slightly soluble in water (insoluble in aqueous
solutions of pH 4 or below); soluble in methanol, dimethyl sulfoxide; administered
orally. The chemical designation is
[R-(R',R')]-2-(4-fluorophenyl)-beta,delta-dihydroxy-5-( 1-methylethyl)-3-phenyl-4
[(phenylamino) carbonyl]- lH-pyrrole-1-heptanoic acid, calcium salt (2:1).
HMG-CoA reductase inhibitors (commonly called "statins") can be classified
in two groups.
- Semi-Synthetic
- Lovastatin (
CAS RN: 75330-75-5)
- Simvastatin
( CAS RN: 79902-63-9)
- Pravastatin Sodium (
CAS RN: 81131-70-6)
- Synthetic
- Fluvastatin
Sodium ( CAS RN: 93957-55-2)
- Atorvastatin Calcium (
CAS RN: 134523-03-8)
- Cerivastatin Sodium
( CAS RN: 143201-11-0)
- Rosuvastatin Calcium (
CAS RN: 147098-20-2)
|
| SALES
SPECIFICATION |
|
APPEARANCE
|
white to
off-white crystalline
powder |
|
IDENTIFICATION
|
Complies
(Test A,B)
|
|
ASSAY
|
98.0%
- 101.0%
|
|
CALCIUM
|
3.3%
- 3.6%
|
|
WATER
|
7.0%
max
|
|
LOSS
ON DRYING
|
0.5%
max
|
| TRANSPORTATION |
| PACKING |
|
| HAZARD CLASS |
|
| UN
NO. |
|
| OTHER
INFORMATION |
|
Hazard
Symbols: , Risk Phrases: , Safety Phrases: 22-24/25 |
|
ANTILIPEMIC AGENTS |
|
|
|
PRICE |
|
|
