ALBENDAZOLE (METHYL 5-PROPYLTHIO-2-BENZIMIDAZOLECARBAMATE)

ALBENDAZOLE
PRODUCT IDENTIFICATION
CAS NO.	54965-21-8 (Base) 54029-12-8 (sulfoxide)
EINECS NO.	259-414-7
FORMULA	C₁₂H₁₅N₃O₂S
MOL WT.	265.33
H.S. CODE
CLASSIFICATION	Anthelmintic / Benzimidazole
TOXICITY	Oral rat LD50: 2400 mg/kg
SYNONYMS	Proftril; AlbendazolumL Albenza; Bilutac;
Methyl 5-propylthio-2-benzimidazolecarbamate; ((Propylthio)-5 1H-benzimidazolyl-2) carbamate de methyle; (5-(Propylthio)-1H-benzimidazol-2-yl)carbamic acid methyl ester; 5-(Propylthio)-2-carbomethoxyaminobenzimidazole; Albendazol; O-Methyl N-(5-(propylthio)-2-benzimidazolyl)carbamate; Zental; Zentel;
PHYSICAL AND CHEMICAL PROPERTIES
PHYSICAL STATE	white to yellowish crystalline powder
MELTING POINT	208 - 210 C
BOILING POINT
SPECIFIC GRAVITY
SOLUBILITY IN WATER
pH
VAPOR DENSITY
AUTOIGNITION
NFPA RATINGS
REFRACTIVE INDEX
FLASH POINT
STABILITY	Stable under ordinary conditions
GENERAL DESCRIPTION & APPLICATIONS
Albendazole is an orally administered broad-spectrum benzimidazole anthelmintic used against helminths and in the treatment of hydatid cyst disease and neurocysticercosis. It is used to treat ruminant infestations by either roundworms or flatworms. It is a white to off-white powder; insoluble in water; soluble in dimethylsulfoxide, strong acids and strong bases; slightly soluble in methanol, chloroform, ethyl acetate and acetonitrile. Chemical designation is Methyl 5-(propylthio)-2-benzimidazolecarbamate. Pharmacological actions of Albendazole: Anthelmintic Anti-Infective Anticestodal Antimitotic Antiparasitic Antiplatyhelmintic Antiprotozoal Mitosis Modulator Tubulin Modulator Anthelmintic (also spelled anthelminthic) is a chemical substance used to expel or destroy tapeworms in domestic animals. Some common anthelmintic active ingredients classified by chemical structure include; Benzimidazoles Albendazole (CAS #: 54965-21-8) Fenbendazole (CAS #: 43210-67-9) Mebendazole (CAS #: 31431-39-7) Oxfendazole (CAS #: 53716-50-0) Oxibendazole ((CAS #: 20559-55-1) Triclabendazole (CAS #: 68786-66-3) Diphenylsulfides Bithionol (CAS #:97-18-7) Febantel (CAS #: 58306-30-2) Hexahydropyrazines Diethylcarbamazine (CAS #: 90-89-1) Piperazine (CAS #: 110-85-0) Praziquantel (CAS #: 55268-74-1) Imidazothiazoles Levamisole (CAS #: 14769-73-4) Tetramisol (CAS #: 5036-02-2) Macrocylic Lactones Abamectin (CAS #: 71751-41-2) Doramectin (CAS #: 117704-25-3) Eprinomectin (CAS #: 123997-26-2) Eprinomectin B_1a (CAS#: 133305-88-1) Eprinomectin B_1b(CAS #: 133305-89-2) Ivermectin (CAS #: 70288-86-7) Ivermectin B_1a (CAS #: 70161-11-4) Ivermectin B_1b (CAS #: 70209-81-3) Moxidectin (CAS #: 113507-06-5) Salicylanilide Closantel (CAS #: 57808-65-8) Niclosamide Base (CAS #: 50-65-7) Niclosamide Monohydrate (CAS #: 7336-56-2) Niclosamide Ethanolamine salt (CAS #: 1420-04-8) Niclosamide Piperazine salt (CAS #: 34892-17-6) Oxyclozanide (CAS #: 2277-92-1) Rafoxanide (CAS #: 22662-39-1) Tetrahydropyrimidines Morantel (CAS #: 20574-50-9) Pytrantel Pamoate (CAS #: 22204-24-6) Others Clorsulon (CAS #: 60200-06-8) Nitroxinil (CAS #: 1689-89-0)
SALES SPECIFICATION (USP)
Albendazole S-Oxide
APPEARANCE	white to off-white powder
IDENTIFICATION	Complies Test A, B
ASSAY	99.0% min
SOLUBILITY	Complies
MELTING POINT	211 C
ASH	0.2% max
LOSS ON DRYING	1.0% max
Albendazole Base
APPEARANCE	white to off-white powder
IDENTIFICATION	Complies Test A, B
ASSAY	98.0 - 101.0%
MELTING POINT	208 - 210 C
RESIDUE ON IGNITION	0.2% max
ASH	0.2% max
TRANSPORTATION
PACKING
HAZARD CLASS
UN NO.	FS0002
OTHER INFORMATION
`Hazard Symbols: T, Risk Phrases: 61-36/37/38`, `Safety Phrases: 53-26-37/39-45`
PRICE