L-PHENYLALANINE

PRODUCT IDENTIFICATION
CAS NO. 63-91-2

L-PHENYLALANINE

EINECS NO. 200-568-1
FORMULA C6H5CH2CH(NH2)COOH
MOL WT. 165.19

H.S. CODE

 2922.49

TOXICITY

  
SYNONYMS (S)-(-)-Phenylalanine; (S)-Phenylalanine;
Phenylalanine; L-(-)-Phenylalanine; L-Phenylalanine; 2-Amino-3-phenylpropanoic acid; beta-phenylalanine; alpha-aminohydrocinnamic acid; L-beta-phenylalanine; alpha-amino-beta-phenylpropionic acid; 3-phenylalanine; phenyl-alpha-alanine; (S)-alpha-aminobenzenepropanoic acid; L-2-Amino-3-phenylpropionic acid; phenyl-L-alanine;
DERIVATION

 

CLASSIFICATION

  

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE White crystalline powder
MELTING POINT 270 - 275 C
BOILING POINT Decomposes
SPECIFIC GRAVITY 0.754
SOLUBILITY IN WATER Slightly
pH  
VAPOR DENSITY

 

REFRACTIVE INDEX

  

NFPA RATINGS

  

AUTOIGNITION

 

FLASH POINT Not expected to be a fire hazard
STABILITY Stable under ordinary conditions

GENERAL DESCRIPTION & APPLICATIONS
Phenylalanine is an essential amino acid obtained in the levo form by hydrolysis of proteins (as lactalbumin). Branched amino-acids (Valine, Isoleucine and Leucine ) with tryptophan and phenylalanine (aromatic side chain amino acids) contribute to the structure of protein by the tendency of its side chain composed only of carbon and hydrogen to participate in hydrophobic interactions which determines the tertiary structure of the peptide chain. In addition to its role in protein synthesis, it is the metabolic precursor of the non-essential amino acid tyrosine which makes hormones, such as norepinephrine and epinephrine in the normal body. Phenylalanine is also converted to phenylethylamine occuring naturally in the brain to elevate mood. It is used to treat depression, inflammation, chronic pain, Parkinson's disease. Phenylalanine is a key intermediate to make aspartame.
SALES SPECIFICATION

BIBLIOGRAPHY

FCC IV

APPEARANCE

 White crystalline powder

ASSAY

98.5 ~ 101.5%

OPTICAL ROTATION

 -32.7 ~ -34.7 °

LOSS ON DRYING

0.3% max

RESIDUE ON IGNITION

0.1% max
ARSENIC
1.5ppm max
LEAD
10ppm max
HEAVY METALS
20ppm max
TRANSPORTATION
PACKING
25kgs in fiber drum
HAZARD CLASS not regulated
UN NO.  
REMARKS
FEMA Number: 3585

GENERAL DESCRIPTION OF AMINO ACID
Amino Acid is any of the organic compounds in which one (or more ) amino group (-NH2) and one (or more ) carboxylic acid group (-COOH) are both present with general formula R-CH(NH2)COOH containing carbon, hydrogen, oxygen, nitrogen, and in certain cases sulfur atoms. Two groups attached to the same carbon (called the alpha-carbon atom at the end of the compound) are polymerized to form peptides and proteins. The amine group is protonated to form -NH3+ at low pH. The carboxylic acid group is deprotonated to form -CO2- at high pH. The carbon atom in the carboxyl group of one amino acid binds covalently to the nitrogen atom in the amino group of another amino acid to form a peptide bond with the release of a water molecule. Proteins are synthesized through the covalent chemical polypeptide bonds. The sequence of these amino acids in the protein polypeptides determines the shape, properties, and hence biological role of the protein that function as chemical messengers and as intermediates in metabolism. Proteins are composed of various proportions of about 20 commonly occurring amino acids. Plants or other biological systems can synthesize amino acids from simple inorganic compounds, but animals rely on adequate supplies in their diet. More than 100 common amino acids occur in plants or in other microorganic systems. The 20 amino acids commonly found in animals are Alanine, Arginine, Asparagine, Aspartic Acid, Cysteine, Glutamic Acid, Glutamine, Glycine, Histidine, Isoleucine, Leucine, Lysine, Methionine, Phenylalanine, Proline, Serine, Threonine, Tryptophan, Tyrosine, and Valine. Many of the amino acids can be synthesized in the human or animal body from other cellular metabolites when needed (called Non-essential Amino Acids). Animals are not able to synthesize some amino acids necessary in metabolism in sufficient quantities. It must therefore be present in the diet (called Essential Amino Acids). In man, these essential amino acids are Arginine, Histidine, Isoleucine, Leucine, Lysine, Methionine, Phenylalanine, Threonine, Tryptophan and Valine.

GENERAL PROPERTIES OF AMINO ACIDS

Amino Acid

Abbreviation

Formula (Mol WT)

pK1

pK2

pKR

pI

Hydropathy Index

3-Letters

1-Letter

-COOH

-NH3+

R group
Alanine

Ala

A

 C3H7NO2 (89.09)

2.34

9.69

-

6.00

1.8
Arginine

Arg

R

 C6H14N4O2(174.20)

2.17

9.04

12.48

10.76

-4.5
Asparagine

Asn

N

 C4H8N2O3(132.12)

2.02

8.80

-

5.41

-3.5
Aspartic Acid

Asp

D

 C4H7NO4(133.10)

1.88

9.60

3.65

2.77

-3.5
Cysteine

Cys

C

 C3H7NO2S(240.30)

1.96

10.128

8.18

5.07

2.5
Glutamic Acid

Glu

E

 C5H9NO4(147.13)

2.19

9.67

4.25

3.22

-3.5
Glutamine

Gln

Q

 C5H10N2O3(146.15)

2.17

9.13

-

5.65

-3.5
Glycine

Gly

G

 C2H5O2(75.07)

2.34

9.60

-

5.97

-0.4
Histidine

His

H

 C6H9N3O2(155.16)

1.82

9.17

6.00

7.59

-3.2
Isoleucine

Ile

I

 C6H13NO2(131.18)

2.36

9.60

-

6.02

4.5
Leucine

Leu

L

 C6H13NO2(131.18)

2.36

9.60

-

5.98

3.8
Lysine

Lys

K

 C6H14N2O2(146.19)

2.18

8.95

10.53

9.74

-3.9
Methionine

Met

M

 C5H11NO2S(149.21)

2.28

9.21

-

5.74

1.9
Phenylalanine

Phe

F

 C9H11NO2(165.19)

1.83

9.13

-

5.48

2.8
Proline

Pro

P

 C5H9NO2(115.13)

1.99

10.60

-

6.30

1.6
Serine

Ser

S

 C3H7NO3(105.19)

2.21

9.15

-

5.58

-0.8
Threonine

Thr

T

 C4H9NO3(119.12)

2.09

9.10

-

5.60

-0.7
Tryptophan

Trp

W

 C11H10N2O2(204.23)

2.83

9.39

-

5.89

-0.9
Tyrosine

Tyr

Y

 C9H11NO3(181.19)

2.20

9.11

10.07

5.66

-1.3
Valine

Val

V

 C5H11NO2(117.15)

2.32

9.62

-

5.96

4.2