3-(ALPHA-ACETONYLBENZYL)-4-HYDROXYCOUMARIN (WARFARIN)

WARFARIN

PRODUCT IDENTIFICATION

CAS NO.

81-81-2; 5543-56-6; 56573-89-8

WARFARIN

EINECS NO. 201-377-6

FORMULA C₁₉H₁₆O₄

MOL WT. 308.33

H.S. CODE

2932.29

TOXICITY

DERIVATION

SYNONYMS 3-(alpha-acetonylbenzyl) -4 -hydroxycoumarin;

4-hydroxy-3-(3-oxo-1-phenylbutyl)-2H-1-Benzopyran-2-one; Coumadin; 3-(a-phenyl-b-acetylethyl)-4-hydroxycoumarin; 3-(1'-phenyl-2'-acetylethyl)-4- Hydroxycoumarin; 4-hydroxy-3-(3-oxo-1-phenylbutyl)-Benzopyran-2-one;

CLASSIFICATION

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE white to off-white crystalline powder

MELTING POINT 161 C

BOILING POINT

SPECIFIC GRAVITY

SOLUBILITY IN WATER Insoluble (Soluble in acetone, alkalinesolutions )

VAPOR DENSITY

AUTOIGNITION

REFRACTIVE INDEX

NFPA RATINGS

FLASH POINT

STABILITY Stable under ordinary conditions

GENERAL DESCRIPTION & APPLICATIONS

Warfarin is a synthetic coumarin anticoagulant which inhibits the hepatic synthesis of the vitamin K–dependent coagulation factors. Its chemical designation is 3-(alpha-acetonylbenzyl) -4 -hydroxycoumarin; racemic mixture of the R and S enantiomers. It is also used as a rodenticide due to the property of causing fatal hemorrhaging. Its salts (sodium or potassium) of warfarin are administered orally, intravenously, or intramuscularly. Warfarin sodium is a white, odorless, crystalline powder; soluble in water, in alcohol; slightly soluble in chloroform and in ether.

SALES SPECIFICATION

APPEARANCE

white to off-white crystalline powder

ASSAY

98.0% min

LOSS ON DRYING

1.0% max

TRANSPORTATION

PACKING

HAZARD CLASS 6.1 (Packing group: I)

UN NO. 3027

OTHER INFORMATION

Hazard Symbols: XN, Risk Phrases: 22/36/38, Safety Phrases: 24/25

GENERAL DESCRIPTION OF COUMARIN

Coumarin (anhydride of o-coumaric acid) is white, crystalline lactone, obtainable naturally from several plants, such as tonka bean, lavender, sweet clover grass, strawberries, and cinnamon, or produced synthetically from an amino acid, phenylalanine. It is the principle of dicumarol which inhibits the hepatic synthesis of the vitamin K–dependent coagulation factors. Coumarin derivatives are used widely as anticoagulants (such as, warfarin, -OH group is attached at 4 position) for the treatment of disorders in which there is excessive or undesirable clotting, such as thrombophlebitis, pulmonary embolism, and certain cardiac conditions. Coumarin derivatives are also used as rodenticides due to the property of causing fatal hemorrhaging. Coumarin has the characteristic odour like that of vanilla beans. It is used for the preparation of perfumes, soaps, flavourings. The coumarin nucleus (benzo-2-pyrone) is derived cinnamic acid (phenylacrylic skeleton) in the biosynthesis. Accordingly, the hydroxy group attached to coumarin structure at 7 position is important in biosynthesis pathway. Umbelliferone (7-hydroxy coumarin), esculetin (6,7-Dihydroxycoumarin), scopoletin (7-hydroxy-6-methoxycoumarin) are the widespread coumarins in nature. Synthetic 7-hydroxy coumarins are used to absorb ultraviolet rays in sunscreen cosmetics and used in the synthesis of drugs especially anticancer.

PRICE

U$2,500.- (1kg)