| CAS
NO. |
104632-26-0
(Base)
104632-25-9 (Dihydrochloride)
191217-81-9
(Dihydrochloride hydrare) |
|
| EINECS NO. |
|
| FORMULA |
C10H17N3S2·HCl·H2O |
| MOL
WT. |
302.27 |
|
H.S.
CODE
|
|
|
TOXICITY
|
|
| SYNONYMS |
Mirapex; (-)-Pramipexole
dihydrochloride hydrate; |
| (6S)-4,5,6,7-Tetrahydro-N6-propyl-2,6-Benzothiazolediamine dihydrochloride
hydrate; (6S)-2-Amino-6-propyltetrahydrobenzothiazole dihydrochloride monohydrate;
(S)-2-Amino-4,5,6,7-tetrahydro-6-(propylamino)benzothiazole
dihydrochloride hydrate; (6S)-N'-propyl-4,5,6,7-tetrahydrobenzothiazole-2,6-diamine hydrate
dihydrochloride; |
| DERIVATION |
|
|
CLASSIFICATION
|
|
|
PHYSICAL AND CHEMICAL PROPERTIES
|
| PHYSICAL
STATE |
white
to off-white crystalline powder |
| MELTING POINT |
|
| BOILING
POINT |
|
| SPECIFIC GRAVITY |
|
| SOLUBILITY
IN WATER |
|
| pH |
|
| VAPOR DENSITY |
|
|
AUTOIGNITION
|
|
|
NFPA
RATINGS
|
|
|
REFRACTIVE
INDEX
|
|
| FLASH
POINT |
|
| STABILITY |
Stable
under ordinary conditions |
|
GENERAL
DESCRIPTION & APPLICATIONS
|
Pramipexole is a nonergot dopamine which stimulate dopamine receptors in the
striatum. It is used as an antidyskinetic for the treatment of Parkinson's
disease. Classes used as antiparkinsonian agents include:
- Anticholinergics
- Antivirals
- Beta-blockers
- COMT (catechol O-methyltransferase) inhibitors
- Dopamine
precursors
- Dopamine agonists
- MAO-B (monoamine oxidase-B)
inhibitors
|
| SALES
SPECIFICATION |
|
APPEARANCE
|
white
to off-white crystalline powder |
|
ASSAY |
98.5%
- 101.5%
|
|
RESIDUE
ON IGNITION
|
0.5%
max
|
|
HEAVY
METALS
|
20ppm
max
|
|
IMPURITY
|
1.0%
max (Total), 0.5% max (Individual)
|
|
OPTICAL
ROTATION
|
-68°
~ -68°
|
| TRANSPORTATION |
| PACKING |
|
| HAZARD CLASS |
|
| UN
NO. |
|
| OTHER
INFORMATION |
|
|