NORDIHYDROGUAIARETIC ACID

PRODUCT IDENTIFICATION
CAS NO. 500-38-9

NORDIHYDROGUAIARETIC ACID
EINECS NO. 207-903-0
FORMULA (CH(CH3)CH2C6H3(OH)2)2
MOL WT. 302.36

H.S. CODE

  

TOXICITY

 Oral rat LD50: 2000mg/kg
SYNONYMS Nordihydroguairaretic acid; NDGA;
beta,gamma-Dimethyl-alpha,delta-bis(3,4-dihydroxyphenyl)butane; 4,4'-(2,3-Dimethyltetramethylene)dipyrocatechol; 4,4'-(2,3-dimethyl-1,4-butanediyl) bis(1,2-benzenediol); 4,4'-(2,3-Dimethyl-1,4-butanediyl)bis-1,2-benzenediol; 2,3-Bis(3,4-dihydroxyphenylmethyl)butane; 2,3-Dimethyl-1,4-bis(3,4-dihydroxyphenyl)butane; 1,4-Bis(3,4-dihydroxyphenyl)-2,3-dimethylbutane;
DERIVATION

 

CLASSIFICATION

  

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE white to off-white powder
MELTING POINT 180 - 185 C
BOILING POINT  
SPECIFIC GRAVITY  
SOLUBILITY IN WATER  
pH  
VAPOR DENSITY

 
AUTOIGNITION

 
NFPA RATINGS Health: 1; Flammability: 0; Reactivity 0

REFRACTIVE INDEX

  
FLASH POINT

 
STABILITY

Stable under ordinary conditions.

GENERAL DESCRIPTION & APPLICATIONS

Nordihydroguaiaretic Acid is used to prevent formation of eicosanoids, prostaglandins, thromboxanes, hydroxyeicosatetraenoic acid and various leukotrienes. It combines with lipoxygenase or cyclooxygenase and thereby serves as a lipoxygenase or cyclooxygenase inhibitor which prevent the substrate-enzyme combination with arachidonic acid. Nordihydroguaiaretic Acid is also known as an antioxidant which inhibit or retard the oxidation of a substance. It also used as an antioxidant in fats and oils.
SALES SPECIFICATION

APPEARANCE

 white to off-white powder
MELTING POINT

175 - 185 C

ASSAY

98.0% min

OPTICAL ROTATION

-1° ~ +1°

RESIDUE ON IGNITION

0.1% max

LOSS ON DRYING

0.5% max

HEAVY METALS

20ppm max

TOTAL MOLD/YEAST

Aerobic Plate Count: 100 organisms/g
Staphylococcusaureus: Negative
Candida albicans: Negative
Aspergllus species: Negative
TRANSPORTATION
PACKING
 
HAZARD CLASS  
UN NO.  
OTHER INFORMATION
Hazard Symbols: XN, Risk Phrases: 22-36/37/38, Safety Phrases: 26-36/37