| CAS
NO. |
51773-92-3;
68682-28-0 |
|
| EINECS
NO. |
257-412-0 |
| FORMULA |
C17H16F6N2O·HCl |
| MOL
WT. |
414.77 |
|
H.S.
CODE
|
2933.40 |
|
TOXICITY
|
Oral
rat LD50: 880 mg/kg |
| SYNONYMS |
Lariam; Mephaquin;
|
| (AS)-rel-a-(2R)-2-peperidinyl-2,8-bis(trifluoromethyl)-4-quinolinemethanol
monohydrochloride; DL-erythro-alpha-2-Piperidyl-2,8-bis(trifluoromethyl)-4-quinolinemethanol
monohydrochloride; (R',S')-(1)-alpha-2-Piperidyl-2,8-bis(trifluoromethyl)quinoline-4-methanol
monohydrochloride; |
| DERIVATION |
|
|
CLASSIFICATION
|
|
|
PHYSICAL AND CHEMICAL PROPERTIES
|
| PHYSICAL
STATE |
white crystalline powder |
| MELTING POINT |
|
| BOILING
POINT |
|
| SPECIFIC GRAVITY |
|
| SOLUBILITY
IN WATER |
slightly soluble |
|
SOLVENT
SOLUBILITY
|
Soluble in lower
alcohol (methanol, ethanol), dimethylformamide, ethyl acetate; sparingly
soluble in isopropanol |
| pH |
|
| VAPOR DENSITY |
|
|
AUTOIGNITION
|
|
|
NFPA
RATINGS
|
|
|
REFRACTIVE
INDEX
|
|
| FLASH
POINT |
|
| STABILITY |
Stable
under ordinary conditions. |
|
GENERAL
DESCRIPTION & APPLICATIONS
|
Mefloquine is a modified 4-quinolonemethanol compound with the chemical
designation of
DL-erythro-alpha-2-Piperidyl-2,8-bis(trifluoromethyl)-4-quinolinemethanol.
Malaria is one of leading re-emerging infectious disease due to murative
malarial parasite developed resistance to chloroquine. It is effective against
chloroquine-resistant strains such as Plasmodium falciparum and P. vivax
malaria. Mefloquine hydrochloride is a white to almost white crystalline
compound, slightly soluble in water; administered orally. Mefloquine molecules
include:
| Mefloquine |
CAS
RN
|
| Mefloquine carboxylic acid |
35853-50-0 |
| (+)-Mefloquine |
51688-68-7 |
| (-)-Mefloquine |
51742-87-1 |
| Mefloquine hydrochloride |
51773-92-3 |
| Mefloquine
base |
53230-10-7 |
| Mefloquine hydrochloride,
sulfadoxine. pyrimethamine combination (Fansimef) |
69191-18-0 |
|
| SALES
SPECIFICATION |
|
APPEARANCE
|
white to almost white crystalline powder |
|
ASSAY
|
98.0
- 102.0% (titration)
|
|
WATER
|
3.0%
max
|
|
SULFATED
ASH
|
0.1%
max
|
|
HEAVY
METALS
|
20ppm max |
|
SOLVENT
RESIDUE
|
acetic acid 0.5% max
dimethylacetamide 0.1% max
methanol 0.1% max |
|
IMPURITY
|
1.0%
max (total impurity)
0.2%
max (individual impurity)
|
| TRANSPORTATION |
| PACKING |
|
| HAZARD CLASS |
|
| UN
NO. |
|
| OTHER
INFORMATION |
|
Hazard
Symbols: XN, Risk Phrases: 22, Safety Phrases: |