D-PHENYLALANINE

PRODUCT IDENTIFICATION
CAS NO. 673-06-3, 10549-11-8

D-PHENYLALANINE 

EINECS NO. 211-603-5
FORMULA C9H11NO2
MOL WT. 165.19

H.S. CODE

 2922.49.3000

TOXICITY

 Intraperitoneal Rat LD50: 5452mg/kg
SYNONYMS Sabiden; H-D-Phe-OH; (R)-2-Amino-3-phenylpropionic acid;
SMILES O=C(O)[C@H](N)Cc1ccccc1

CLASSIFICATION

 Amino Acids

PHYSICAL AND CHEMICAL PROPERTIES
PHYSICAL STATE white crystalline powder
MELTING POINT 273 - 276 C
BOILING POINT

 

SPECIFIC GRAVITY  
SOLUBILITY IN WATER 2.82E+04

SOLUBILITY IN SOLVENT

 slightly soluble in methanol
pH  
VAPOR DENSITY

 

pKa  
log Pow -1.280 (Octanol-water)
VAPOR PRESSURE 8.87E-09 (mmHg)
HENRY'S LAW (atm-m3/mole at 25 C)
OH RATE 4.42E-11 (cm3/molecule-sec at 25 C Atmospheric)

AUTOIGNITION

  

NFPA RATINGS

 Health: 1; Flammability: 0; Reactivity: 0

REFRACTIVE INDEX

 

FLASH POINT

 

STABILITY

Stable under ordinary conditions.

GENERAL DESCRIPTION & APPLICATIONS

Phenylalanine is an essential amino acid (a building block for proteins in the body), meaning the body needs it for health but cannot make it. You have to get it from food. Phenylalanine is found in three forms: L-phenylalanine, the natural form found in proteins; D-phenylalanine (a mirror image of L-phenylalanine that is made in a laboratory), and DL-phenylalanine, a combination of the two forms. The body changes phenylalanine into tyrosine, another amino acid that's needed to make proteins, brain chemicals including L-dopa, epinephrine, and norepinephrine, and thyroid hormones. Because norepinephrine affects mood, different forms of phenylalanine have been proposed to treat depression. Symptoms of phenylalanine deficiency include confusion, lack of energy, depression, decreased alertness, memory problems, and lack of appetite. On the other hand, a rare metabolic disorder called phenylketonuria (PKU) occurs in people who are missing an enzyme that the body needs to use phenylalanine. That causes high levels of phenylalanine to build up. If it is not treated before 3 weeks of age, PKU can cause severe, irreversible mental retardation. In the United States, newborns are tested for PKU during the first 48 - 72 hours of life. People with PKU must eat a diet that avoids phenylalanine and take tyrosine supplements to have optimum brain development and growth. http://www.umm.edu

Wikipedia Linking: http://en.wikipedia.org/wiki/Phenylalanine

Material Safety Data Sheet: http://www.chemcas.org/

chemistry/function:
• L-phenylalanine is an essential amino acid that plays a key role in the biosynthesis of other amino acids, including L-tyrosine, and related biochemical processes involving the synthesis of several important neurotransmitters, principally L-dopa, dopamine, epinephrine and norepinephrine. Through a different metabolic pathway, L-phenylalanine can also be converted to phenylethylamine. Phenylethylamine is a naturally occurring substance in the brain that appears to elevate mood. Along with another amino acid, tryptophan, phenylalanine also governs the release of cholecystokinin, an intestinal hormone also known as CCK.
• D-phenylalanine, the mirror image of L-phenylalanine, does not occur naturally in the body. Further, it does not feed into the process of synthesizing L-tyrosine, L-dopa, or norepinephrine.
• DLPA is a mixture of the essential amino acid L-phenylalanine and its mirror image D-phenylalanine. DLPA does not occur naturally in the body. http://home.caregroup.org/
SALES SPECIFICATION

APPEARANCE

 White to off-white crystalline powder
SPECIFIC ROTATION +32° ~ +35° (20°C, 589 nm) (c=2, water)

LOSS ON DRYING

0.5% max
RESIDUE ON IGNITION

0.1% max
HEAVY METAL

10ppm max

ASSAY

 98.5 - 101.0%
TRANSPORTATION
PACKING
 
HAZARD CLASS Not regulated
UN NO.  
OTHER INFORMATION